SOLUBILITY ENHANCEMENT BY SOLID DISPERSION METHOD: A REVIEW
نویسندگان
چکیده
منابع مشابه
Carvedilol Solubility Enhancement by Inclusion Complexation and Solid Dispersion: Review
Carvedilol is an effective nonselective alpha-1 and beta blocker discovered by Fritz Wiedemann [1] . It is an antihypertensive drug indicated for the treatment of mild to severe congestive heart failure (CHF), angina pectoris, cardiac arrhythmias and myocardial infarction [2] . Water solubility of Carvedilol is a fundamental property that affects the drug absorption after oral administration. M...
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Solid dispersions have been employed to enhance the dissolution rates of poorly water-soluble drugs. Many approaches have been investigated for the preparation of solid dispersions. This paper reports the various solubility enhancement strategies in solid dispersion. The approaches described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration process, e...
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Over 40% of active pharmaceutical ingredients in development are poorly water soluble drugs which limit formulation approaches, clinical application and marketability because of their low dissolution and bioavailability. Solid dispersion has been considered one of the major advancements in overcoming these issues with several successfully marketed products. Extensive review of the literature in...
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The solubility behaviour of drug is one of the most challenging aspects in formulation development. Thus a greater understanding of dissolution and absorption behaviour of drug with low aqueous solubility is required to successfully formulate them into more soluble and hence bioavailable drug product. Therefore different approaches are being explored to enhance the solubility of poorly water so...
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2013
ISSN: 2250-1177
DOI: 10.22270/jddt.v3i5.632